In 430 BC, Athens was destroyed by a plague. It is estimated that about 100,000 people died of the disease, a detailed documented by historian thucydides, who himself contracted the disease but survived. No one knows what the disease is, but many theories believe that Ebola, typhoid fever and smallpox are one of the sources of the outbreak. Symptoms include vomiting, sneezing, severe coughing and pustules on the body, and the victims include Pericle, the city's beloved leader. In this deadly plague, no Athenians survived and the entire city fell into chaos.

In Chapter 5 of Assassin's Creed: Odyssey, players can experience the Athenian Plague for themselves. Previously, Athens was one of the most active and bustling places in the game, with citizens, soldiers and merchants everywhere. Walking on the street, you will hear the sound of children playing, the barking of chickens and dogs, and the silence of people chatting. But when Cassandra/Alixios returns to Athens again in the mission of Abandoned By The Gods, the scene in the city is like adding a filter. The streets were dead, and the bodies of some plague patients were placed randomly everywhere.

Recently, a British player was deeply moved by the plague scene in the game while replaying this chapter. "When I strolled along the empty streets of Athens, I couldn't help but remember what happened in March 2019 - when Britain entered its first national lockdown - I was also upset by the silence of the city. I live in Yorkshire, which is usually crowded with tourists, but now even Shambles, known for its crowds, is indifferent. I have always loved the Assassin's Creed series that allows players to relive history and experience these events firsthand, but the game is a bit too close to reality. When Cassandra left Athens, I was very happy to go to other places in Greece."

Assassin's Creed Odyssey's artists make everything appear a pathological, unsaturated look by adding heavy color ratings to the screen. The drizzle of rain and the gloomy silence in the streets will only add a sense of hopeless desolation. Occasionally, Athenian citizens would be seen insulting the gods on the street, holding their heads in their hands, or lying among a pile of corpses waiting to die. This is a vivid portrayal of a dark period in Greek history. Many historians believe that the epidemic ultimately led to Athens' defeat by Sparta in the Peloponnese War.