Isaac's union of rebirth Magdalene unlocking method. There are many characters in the game that can be used, but certain conditions are required to be reached before unlocking. The following editor will bring you the method of unlocking the combination of Isaac Magdalene.

Magdalene

or Maggie, it is unlocked after gaining 7 heart containers in a single game.

Born items: None

Born with props: Active props Delicious Heart (Yum Heart).